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Androgen receptor post-translational modifications and their implications for pathology

Inés Montoya-Novoa1,2, José Luis Gardeazábal-Torbado1,2, Andrea Alegre-Martí1,2

  • 1Structural Biology of Nuclear Receptors, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona (UB), 08028 Barcelona, Spain.

Biochemical Society Transactions
|July 3, 2024
PubMed

Insights

Post-translational modifications (PTMs) significantly impact the androgen receptor's (AR) function. This review details AR PTMs, their cross-talk, and implications for diseases like prostate cancer.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Cell Biology

Background:

  • The androgen receptor (AR) is a crucial transcription factor regulating numerous biological processes.
  • Post-translational modifications (PTMs) are key regulatory mechanisms influencing AR activity.
  • Dysregulation of AR signaling is implicated in various diseases, notably prostate cancer.

Purpose of the Study:

  • To review the current understanding of PTMs affecting the androgen receptor.
  • To elucidate the structural and functional consequences of AR PTMs.
  • To explore the implications of AR PTMs in disease pathogenesis and therapeutic strategies.

Main Methods:

  • Comprehensive literature review of studies on androgen receptor post-translational modifications.
  • Analysis of existing data on the structural and functional impacts of various PTMs.
  • Synthesis of information regarding PTM cross-talk and residue clustering within the AR protein.

Main Results:

  • PTMs represent a major mechanism for modulating AR biological activities.
  • Specific PTMs, their cross-talk, and clustered modifications significantly impact AR structure and function.
  • These modifications are implicated in the development of diseases such as spinal and bulbar muscular atrophy and prostate cancer.

Conclusions:

  • Understanding AR PTMs is critical for deciphering AR-mediated signaling pathways.
  • PTMs offer potential therapeutic targets for AR-dependent diseases.
  • Further research into AR PTMs could lead to novel pharmacological interventions.
Keywords:
androgen insensitivity syndromeandrogen receptorcrystallographypost translational modificationprostate cancerspinal and bulbar muscular atrophy

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