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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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Infective endocarditis associated with left atrial appendage occlusion device: a contemporary systematic review

Alejandro Sanchez-Nadales1, Muftawu Iddrisu2, Roshan Wardak3

  • 1Department of Cardiology, Department of Cardiovascular Disease, Cleveland Clinic Florida, Weston, Weston Campus, FL, 33324, USA.

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
|July 3, 2024
PubMed

Insights

Infective endocarditis (IE) after left atrial appendage occlusion (LAAO) is rare, with Staphylococcus aureus being the main cause. Early diagnosis via echocardiography and prompt treatment are crucial for managing this device-related infection.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Device Technology

Background:

  • Limited data exists on infective endocarditis (IE) complicating left atrial appendage occlusion (LAAO) procedures.
  • This systematic review investigates the causes, diagnosis, and treatment of IE following LAAO.

Approach:

  • A systematic literature search was conducted across six databases from 2007 to 2022.
  • Studies detailing IE in LAAO patients with clinical and imaging data were included.
  • Exclusion criteria involved non-primary research articles like editorials and abstracts.

Key Points:

  • Seven cases of IE complicating LAAO were identified globally between 2007 and 2022.
  • Staphylococcus aureus was the predominant pathogen identified in LAAO-related infections.
  • Echocardiography is essential for diagnosing IE in patients with LAAO devices.

Conclusions:

  • The scarcity of data necessitates prospective trials for evidence-based guidelines on IE prophylaxis, diagnosis, and management.
  • Increased vigilance for device-related infections is crucial given the rising use of LAAO devices worldwide.
Abstract

Keywords:
18F-FDG-PET imagingAtrial fibrillationEchocardiographyInfective endocarditisLeft atrial appendage occlusion deviceMultimodality cardiovascular imaging

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