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Advance on Chinese Medicine for Hypertensive Renal Damage: Focus on the Complex Molecular Mechanisms

Yan Lu1, Xue-Na Xie2, Qi-Qi Xin1,3

  • 1Laboratory of Cardiovascular Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, 100091, China.

Chinese Journal of Integrative Medicine
|July 3, 2024
PubMed

Insights

Hypertensive renal damage (HRD) is a leading cause of kidney failure. Chinese medicine offers promising, multi-targeted treatments for HRD, addressing its complex mechanisms.

Area of Science:

  • Nephrology
  • Integrative Medicine
  • Pharmacology

Background:

  • Hypertensive renal damage (HRD) is a significant contributor to end-stage renal disease, accounting for approximately 34% of cases.
  • Current drug-based antihypertensive treatments often exhibit limited efficacy and undesirable side effects.
  • Chinese medicine (CM) presents a promising alternative due to its multi-targeted and multi-channel therapeutic properties.

Purpose of the Study:

  • To review and discuss recent advances in the basic research mechanisms of CM interventions for HRD.
  • To explore the potential of CM in managing hypertensive renal damage.
  • To identify challenges and future prospects for CM in HRD treatment.

Main Methods:

  • Literature review of basic research on CM for HRD.
  • Analysis of CM's mechanisms of action, including multi-target regulation.
  • Synthesis of findings on CM's efficacy and safety in HRD management.

Main Results:

  • CM exhibits potential through mechanisms such as regulating the renin-angiotensin-aldosterone system, antioxidation, and anti-inflammation.
  • CM can rescue endothelial function and modulate vasoactive substances and obesity-related factors.
  • Numerous CM, used individually or in formulations, are employed for HRD treatment.

Conclusions:

  • CM offers a complex yet advantageous therapeutic approach for HRD.
  • Further research into CM's mechanisms can enhance its clinical application for hypertensive renal damage.
  • CM holds significant promise for improving outcomes in patients with HRD.

Keywords:
Chinese medicinehypertensive renal damagemolecular mechanismsresearch progress

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