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Polo-Like Kinase 1 and DNA Damage Response

Wei Li1,2, Yongjian Hao2

  • 1Laboratory of Nuclear and Radiation Damage, Characteristic Medical Center, PLA Rocket Force, Beijing, China.

DNA and Cell Biology
|July 3, 2024
PubMed

Insights

Polo-like kinase 1 (Plk1) is crucial for cell cycle mitosis and DNA damage response. This review highlights Plk1

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Polo-like kinase 1 (Plk1) is a serine/threonine kinase regulating cell cycle mitosis.
  • Emerging evidence implicates Plk1 in non-mitotic processes, including DNA damage response (DDR).
  • DDR encompasses checkpoint activation, repair, recovery, and apoptosis.

Purpose of the Study:

  • To review the multifaceted roles of Plk1 in cellular responses to DNA damage.
  • To elucidate Plk1's function within the DNA damage response pathways.

Main Methods:

  • Literature review of studies investigating Plk1's function in DNA damage response.
  • Analysis of Plk1's interactions with key DNA repair proteins and checkpoint regulators.

Main Results:

  • Plk1 is a target of the G2/M DNA damage checkpoint.
  • Plk1 negatively regulates Ataxia telangiectasia-mutated (ATM) kinase activity.
  • Plk1 promotes G2/M checkpoint recovery and homologous recombination repair via Rad51 and BRCA1 interactions.

Conclusions:

  • Plk1 plays a significant role in managing DNA damage.
  • Plk1 integrates cell cycle control with DNA repair mechanisms.
Keywords:
DNA damage checkpointDNA repairPlk1homologous recombination

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