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  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Specific Immunological Characteristics And Risk Factor Of Xbb Variants Re-infection In Nasopharyngeal Carcinoma Patients After Ba.5 Infection.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Specific Immunological Characteristics And Risk Factor Of Xbb Variants Re-infection In Nasopharyngeal Carcinoma Patients After Ba.5 Infection.

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Specific immunological characteristics and risk factor of XBB variants re-infection in nasopharyngeal carcinoma patients after BA.5 infection.

Yu Lei1, Nansong Xu2, Chuanying Niu3

  • 1State Key Laboratory of Respiratory Disease, Clinical Laboratory Medicine Department, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, PR China.

Virology
|July 3, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Inactivated vaccination boosts SARS-CoV-2 specific antibodies in nasopharyngeal carcinoma patients after BA.5 infection. Low globulin levels predict XBB variant re-infection risk in these individuals.

Keywords:
BA.5 variantHumoral immunityNasopharyngeal carcinomaRe-infection

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Area of Science:

  • Immunology
  • Virology
  • Oncology

Background:

  • Nasopharyngeal carcinoma (NPC) patients present unique challenges in managing SARS-CoV-2 infections.
  • Understanding the humoral immune response and re-infection risks in these patients is crucial for effective clinical management.

Purpose of the Study:

  • To explore the humoral immune response after inactivated vaccination and BA.5 infection in NPC patients.
  • To identify predictors of re-infection with XBB variants in BA.5 infection-recovered NPC (BA.5-RNPC) patients.

Main Methods:

  • Serum SARS-CoV-2 specific antibody levels were measured using enzyme-linked-immunosorbent-assay.
  • Univariate and multivariate logistic regression analyses identified factors associated with antibody levels and XBB re-infection risk.
XBB.1.1.6 variant

Main Results:

  • BA.5-RNPC patients showed comparable antibody levels to non-cancerous individuals, with higher levels of specific antibodies (anti-ancestral-S1-IgG, anti-nucleocapsid-protein-IgG, anti-BA.5-RBD-IgG, anti-XBB.1.1.6-RBD-IgG) compared to uninfected controls.
  • Inactivated vaccination significantly increased anti-ancestral-S1-IgG and anti-XBB.1.16-RBD-IgG levels.
  • Inactivated vaccination was the strongest predictor of SARS-CoV-2 specific antibody response, while low globulin levels independently predicted XBB re-infection risk.

Conclusions:

  • Vaccinated BA.5-RNPC patients exhibit enhanced SARS-CoV-2 specific antibody levels.
  • Baseline immunoglobulin G (IgG) levels serve as a biomarker for predicting XBB variant re-infection risk in BA.5-RNPC patients.