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The In ovo CAM-assay as a Xenograft Model for Sarcoma

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Angiosarcoma: hiding in plain sight.

Tue F Nguyen, Pavela G Bambekova, Chad M Hivnor

¹Division of Dermatology & Cutaneous Surgery, University of Texas Health San Antonio, San Antonio, Texas, USA South Texas Veterans Health Care System, San Antonio, Texas, USA. joshua.owen1@va.gov.

Dermatology Online Journal

|July 3, 2024

Summary

This summary is machine-generated.

Cutaneous angiosarcoma is a rare cancer. Early diagnosis is crucial, especially in patients with Skin of Color, as histopathology can be challenging, requiring immunohistochemistry for confirmation.

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Area of Science:

Oncology
Dermatopathology
Surgical Pathology

Background:

Angiosarcoma is a rare, aggressive vascular endothelial malignancy.
It often presents on the head and neck, particularly in elderly individuals.
Cases in patients with Skin of Color are less commonly reported.

Observation:

A case of an 83-year-old male (Fitzpatrick skin type IV) with a scalp lesion is presented.
The lesion was a large, violaceous-to-black, mamillated plaque, clinically suspicious for angiosarcoma.
Initial histopathology was inconclusive, delaying diagnosis and management.

Findings:

Immunohistochemistry was essential for confirming the diagnosis of angiosarcoma.
This highlights the diagnostic challenges that can arise.
Cutaneous angiosarcoma demonstrates aggressive behavior with a propensity for recurrence and metastasis.

Implications:

Emphasizes the need for high clinical suspicion for angiosarcoma, especially in diverse populations.
Underscores the importance of clinicopathologic correlation and advanced diagnostic tools like immunohistochemistry.
Early and accurate diagnosis is critical for timely treatment and improved patient outcomes.