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Related Experiment Video

Updated: Jun 22, 2025

In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells
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Comparing Deposition Characteristics of Various Embolic Particles Using an In Vitro Prostate Microvasculature Model.

Samuel R Miller1, Shaphan R Jernigan1, Robert J Abraham2

  • 1Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina.

Journal of Vascular and Interventional Radiology : JVIR
|July 3, 2024
PubMed
Summary

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Radiopaque glass (RG) microspheres showed greater distal penetration in a hyperplastic hemiprostate model compared to tris-acryl gelatin (TAG) and polyvinyl alcohol (PVA) particles. Non-compressible particles with smaller diameters achieved better distal packing.

Area of Science:

  • Interventional Radiology
  • Vascular Embolization
  • Prostate Artery Embolization

Background:

  • Hyperplastic prostate disease necessitates effective treatment strategies.
  • Vascular embolization is a key therapeutic approach for managing benign prostatic hyperplasia.
  • Understanding embolic particle behavior is crucial for optimizing embolization outcomes.

Purpose of the Study:

  • To compare the spatial distribution of radiopaque glass (RG) microspheres, tris-acryl gelatin (TAG) microspheres, and polyvinyl alcohol (PVA) particles.
  • To evaluate embolic particle behavior within an in vitro microvascular model of the hyperplastic hemiprostate.

Main Methods:

  • Utilized a planar in vitro microvascular model simulating hyperplastic hemiprostate.
  • Administered various sizes of RG, TAG, and PVA particles via microcatheter.

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  • Quantified particle distribution and distal penetration using microscopic imaging and semantic segmentation.

    • Main Results:

    • 50 μm RG microspheres demonstrated maximum distal penetration.
    • Larger TAG (300-500 μm) and PVA particles exhibited the least distal penetration.
    • Significant differences in distal penetration were observed between most particle groups (P < .05).

    Conclusions:

    • Non-compressible particles with narrower size calibrations and smaller diameters achieve greater distal packing.
    • Wider particle size calibrations result in less distinct embolization fronts and varied emboli sizes.
    • PVA particles and larger TAG microspheres showed limited distal penetration in this model.