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  11. "all-in-one" Self-healing And Injectable Cationic Guar Gum Hydrogel Dressing Functionalized By Bioactive Complexes Composed Of Natural Small Molecules

"All-in-one" self-healing and injectable cationic guar gum hydrogel dressing functionalized by bioactive complexes composed of natural small molecules

Yan Wang1, Mingrui Yang1, Zhifei Yang1

  • 1State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, China.

International Journal of Biological Macromolecules
|July 3, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

This study developed a novel polysaccharide hydrogel (FA-TOB/CG) for infectious wound healing. The hydrogel effectively eliminates bacteria and promotes healing by providing a moist environment and releasing beneficial compounds.

Area of Science:

  • Biomaterials Science
  • Wound Healing Research
  • Antimicrobial Hydrogels

Background:

  • Infectious wounds pose a significant health challenge, necessitating advanced wound care solutions.
  • Polysaccharide-based hydrogels offer biocompatibility, biodegradability, and antimicrobial properties for wound management.
  • Developing effective antibacterial hydrogels is crucial for reducing infection risk and promoting tissue regeneration.

Purpose of the Study:

  • To develop an "all-in-one" self-adaptive and injectable cationic guar gum (CG)-based hydrogel for infectious wound healing.
  • To incorporate antioxidant and antibacterial ferulic acid (FA)-tobramycin (TOB) bioactive complexes into the hydrogel matrix.
  • To evaluate the antimicrobial, antioxidant, and wound healing capabilities of the developed hydrogel.

Main Methods:

Keywords:
AntibacterialCationic guar gumFerulic acidTobramycin

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  • Construction of ferulic acid (FA)-tobramycin (TOB) bioactive complexes.
  • Fabrication of FA-TOB/CG hydrogel using cationic guar gum (CG) and FA-TOB complexes.
  • Assessment of hydrogel's sterilization rates against Staphylococcus aureus and Escherichia coli.
  • Evaluation of antioxidant activities using DPPH, ABTS, and hydroxyl radical scavenging assays.
  • Analysis of sustained release of FA and TOB from the hydrogel.
  • In vivo assessment of wound healing promotion, including collagen deposition and vascular regeneration.

Main Results:

  • The FA-TOB/CG hydrogel demonstrated high sterilization rates against S. aureus (98%) and E. coli (80%).
  • The hydrogel exhibited significant antioxidant performance, with DPPH scavenging > 40%, ABTS scavenging > 90%, and hydroxyl radical scavenging > 50%.
  • Sustained release of FA and TOB was observed from the FA-TOB/CG hydrogel.
  • The hydrogel promoted wound healing by creating a moist environment, eliminating bacteria, reducing inflammation, and accelerating tissue regeneration.

Conclusions:

  • The developed FA-TOB/CG hydrogel is a promising multifunctional dressing for infected wounds.
  • Incorporating bioactive complexes into polysaccharide hydrogels offers a novel strategy for advanced wound care.
  • This approach enhances antibacterial efficacy, antioxidant properties, and promotes effective wound healing.
Wound healing