A single-blinded, randomized, parallel intervention to evaluate genetics and omics-based personalized nutrition in...

Area of Science:

• Nutritional Science
• Genomics
• Metabolomics
• Personalized Medicine

Background:

• Personalized nutrition (PN) aims to enhance dietary recommendation effectiveness for improved health.
• Omics data (genetics, metabolomics, proteomics) can inform personalized dietary strategies.

Purpose of the Study:

• To evaluate if omics-based PN integrated into an e-commerce tool improves dietary behavior and metabolic profiles in the general population.
• To assess the impact of personalized nutrition (PN) and a personalized plan (PP) on Mediterranean diet adherence and health markers.

Main Methods:

• A 21-week randomized intervention with 193 adults comparing a control group (Mediterranean diet), PN group, and PP group (PN + behavioral change program).
• Utilized metabolomics, proteomics, and genetic data to create personalized shopping lists via a simulated e-commerce platform.
• Primary outcome: Mediterranean Diet Adherence Screener (MEDAS) score; Secondary outcomes: biometric, metabolic markers, and dietary habits.

Main Results:

• All groups showed significant increases in MEDAS scores; no significant differences in overall dietary habits or health parameters between PN and control groups.
• Personalized recommendations significantly enhanced biomarker scores related to carbohydrate metabolism, oxidative stress, microbiota, and inflammation compared to the control diet.
• The e-commerce tool integration did not yield superior adherence or health improvements over general recommendations.

Conclusions:

• Integrating personalized strategies via an e-commerce tool did not enhance Mediterranean diet adherence or improve general health markers compared to standard recommendations.
• The metabotyping approach shows potential, warranting further research for application in personalized nutrition.
• The study provides valuable insights into the efficacy of omics-based personalized nutrition strategies.