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Continuous renal replacement therapy with vitamin E-coated polysulfone hemofilter reduces inflammatory responses in a
Takumi Horikawa1, Kana Yagi1, Chika Ishikawa1
1Medical Technology and Material Laboratory, Research and Business Development Division, Asahi Kasei Medical Co., LTD., Shizuoka, Japan.
Introduction:
Biological invasions may promote the onset of systemic inflammatory response syndrome in patients eligible for continuous renal replacement therapy (CRRT), leading to poor prognosis. Hence, we aimed to examine the inflammatory reactions in circulation using vitamin E-coated polysulfone hollow fiber membrane (ViLIFE).
Methods:
Lipopolysaccharides were intravenously administered to pigs (2 μg/kg/30 min) to establish an acute inflammation model. Extracorporeal circulation was performed for 6 h in continuous venovenous hemodiafiltration mode using a hemofilter for CRRT filled with a polysulfone hollow fiber membrane or ViLIFE, and the differences in inflammatory reactions were evaluated.
Results:
The ViLIFE group exhibited low platelet and cytokine levels (p < 0.05 vs. sham-CRRT group). Additionally, the ViLIFE group had lower lactate and high mobility group box 1 levels than the other groups.
Conclusion:
ViLIFE represents a promising CRRT modality that can inhibit the inflammatory response in circulation and inhibit further biological invasions.
Insights
Vitamin E-coated polysulfone hollow fiber membranes (ViLIFE) show promise in managing inflammation during continuous renal replacement therapy (CRRT). This novel approach may improve patient outcomes by reducing inflammatory markers and biological invasions.
Area of Science:
- Biomedical Engineering
- Nephrology
- Critical Care Medicine
Background:
- Biological invasions can trigger systemic inflammatory response syndrome in patients undergoing continuous renal replacement therapy (CRRT), negatively impacting prognosis.
- Investigating novel biocompatible materials is crucial for mitigating CRRT-associated inflammation.
Purpose of the Study:
- To evaluate the efficacy of vitamin E-coated polysulfone hollow fiber membranes (ViLIFE) in modulating inflammatory responses during CRRT.
- To assess the impact of ViLIFE on circulating inflammatory markers in an acute inflammation model.
Main Methods:
- An acute inflammation model was induced in pigs via intravenous lipopolysaccharide administration.
- Extracorporeal circulation was conducted for 6 hours using continuous venovenous hemodiafiltration with either standard polysulfone or ViLIFE hemofilters.
- Inflammatory reactions were assessed by comparing marker levels between groups.
Main Results:
- The ViLIFE group demonstrated significantly lower levels of platelets and cytokines compared to the sham-CRRT group (p < 0.05).
- ViLIFE treatment resulted in reduced levels of lactate and high mobility group box 1 (HMGB1) compared to control groups.
- These findings suggest a potent anti-inflammatory effect of the ViLIFE membrane.
Conclusions:
- ViLIFE is a promising new modality for CRRT, effectively inhibiting systemic inflammatory responses.
- The ViLIFE membrane shows potential in preventing further biological invasions associated with inflammation during CRRT.
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