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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Role Of Ultrasound In Predicting Telomerase Reverse Transcriptase (tert) Promoter Mutation In Follicular Thyroid Carcinoma.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Role Of Ultrasound In Predicting Telomerase Reverse Transcriptase (tert) Promoter Mutation In Follicular Thyroid Carcinoma.

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Role of ultrasound in predicting telomerase reverse transcriptase (TERT) promoter mutation in follicular thyroid carcinoma.

Myoung Kyoung Kim1, Hyunju Park2, Young Lyun Oh3

  • 1Department of Radiology and Center for Imaging Science, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Scientific Reports
|July 3, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Telomerase reverse transcriptase (TERT) promoter mutations in follicular thyroid cancer (FTC) are linked to aggressive tumors. Ultrasonography can identify specific features, like microlobulated margins and punctate echogenic foci, that predict these mutations.

Keywords:
Follicular thyroid carcinomaTelomerase reverse transcriptase promoter mutationThyroid Imaging Reporting and Data SystemUltrasound

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Area of Science:

  • Oncology
  • Radiology
  • Genetics

Background:

  • Telomerase reverse transcriptase (TERT) promoter mutations are recognized indicators of tumor aggressiveness in various cancers.
  • Follicular thyroid cancer (FTC) aggressiveness can be influenced by genetic mutations, including those in the TERT promoter.
  • Understanding the ultrasonographic (US) characteristics associated with TERT promoter mutations in FTC is crucial for improved diagnosis and patient management.

Purpose of the Study:

  • To identify and characterize the ultrasonographic (US) features of TERT promoter-mutated follicular thyroid cancer (FTC).
  • To evaluate the predictive performance of US findings in identifying TERT promoter mutations in FTC.
  • To correlate specific US features with the presence of TERT promoter mutations in FTC.

Main Methods:

  • A retrospective analysis of 63 surgically confirmed FTC cases was conducted.
  • Preoperative US findings and TERT promoter mutation status (determined by genomic DNA analysis) were collected and analyzed.
  • Logistic regression was used to compare US features between TERT promoter-mutated and wild-type FTC, identifying independent risk factors.

Main Results:

  • Ten out of 63 FTC patients (15.9%) harbored TERT promoter mutations.
  • TERT promoter-mutated FTCs were more frequently classified into high suspicion categories by K-TIRADS and ACR-TIRADS.
  • Microlobulated margins and punctate echogenic foci were identified as independent US risk factors for TERT promoter mutations in FTC.

Conclusions:

  • Ultrasonography can reveal specific features associated with TERT promoter mutations in follicular thyroid cancer.
  • Microlobulated margins and punctate echogenic foci are significant predictors of TERT promoter mutations in FTC.
  • These US findings aid in categorizing FTC risk and may guide further diagnostic and therapeutic strategies.