The association between systemic inflammation markers and paroxysmal atrial fibrillation
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View abstract on PubMed
Summary
This summary is machine-generated.Systemic inflammation markers like SII and SIRI are positively correlated with paroxysmal atrial fibrillation (PAF) risk. These markers show potential for early PAF detection, with increased risk observed in higher tertiles.
Area Of Science
- Cardiology
- Inflammation Research
- Biomarker Discovery
Background
- Systemic inflammation is linked to cardiac disorders.
- Limited research exists on pre-diagnostic associations between inflammation markers and paroxysmal atrial fibrillation (PAF).
Purpose Of The Study
- To identify potential biomarkers for early detection of PAF.
- To investigate associations between systemic inflammation markers and PAF.
Main Methods
- Correlations between systemic immune inflammation index (SII), systemic inflammation response index (SIRI), aggregate index of systemic inflammation (AISI), and PAF were investigated.
- 91 participants with PAF and 97 without were included.
- Restricted cubic splines and ROC curve analyses were performed.
Main Results
- PAF incidence increased with higher tertiles of logSII, logSIRI, and logAISI.
- Highest tertiles of logSII and logSIRI showed 3.2-fold and 2.9-fold increased PAF risk, respectively.
- ROC analysis indicated favorable sensitivity and specificity for SII, SIRI, and AISI in detecting PAF.
Conclusions
- Significant positive correlations exist between SII, SIRI, AISI, and PAF incidence.
- These inflammation markers show promise for early PAF detection.
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