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Improvement in idiopathic interstitial pneumonia by adding macitentan to a patient unresponsive to nintedanib

Yosuke Tanaka1,2, Shota Kaburaki2, Toru Tanaka2

  • 1Department of Respiratory Medicine, Nippon Medical School, Chiba Hokusoh Hospital, 1715 Kamagari, Inzai, Chiba, 270-1694, Japan.

Respiratory Medicine Case Reports
|July 4, 2024
PubMed

A 69-year-old woman was diagnosed with idiopathic interstitial pneumonia (IIP). The patient underwent a combination therapy of steroid therapy and intravenous cyclophosphamide, long-term oxygen therapy, and the initiation of Nintedanib. However, there was no improvement in IIP, and as a result, the activities of daily living also declined. As one of the various examinations conducted, the results of the right heart catheterization diagnosed the patient with mild pulmonary hypertension, and Macitentan therapy was initiated. The subsequent clinical course appeared to show an improvement in Idiopathic Interstitial Pneumonia (IIP) by adding Macitentan therapy to Nintedanib therapy.

Keywords:
Endothelin receptor antagonistInterstitial pneumoniaMacitentanPulmonary hypertension

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