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Anticoagulation in Atrial Fibrillation Associated With Cardiac Amyloidosis: A Narrative Review
Tejbir S Monga1, Mfonido Ekong2, Kayé Patrick3
1Internal Medicine, Spartan Health Sciences University, Vieux Fort, LCA.
Cureus
|July 4, 2024
Summary
Cardiac amyloidosis (CA) patients with atrial fibrillation (AF) require anticoagulation to prevent clots. Safe anticoagulant use is crucial for managing AF in CA, irrespective of risk scores, to minimize complications.
Area of Science:
- Cardiology
- Hematology
- Pharmacology
Background:
- Cardiac amyloidosis (CA) is characterized by amyloid protein deposition in the heart.
- Progressive CA leads to heart dysfunction, arrhythmias like atrial fibrillation (AF), and heart failure.
- Atrial fibrillation in CA patients elevates the risk of intracardiac thrombi and thromboembolic events.
Purpose of the Study:
- To review atrial fibrillation in cardiac amyloidosis.
- To discuss anticoagulation therapy for managing thromboembolic risk in CA patients with AF.
- To emphasize safe anticoagulation practices and multidisciplinary care.
Main Methods:
- Literature review on atrial fibrillation in cardiac amyloidosis.
- Analysis of anticoagulation strategies for CA patients.
- Discussion of risk assessment and management of adverse events.
Main Results:
- Atrial fibrillation is a common complication in cardiac amyloidosis.
- Anticoagulation is essential for reducing thromboembolic risk in these patients.
- Safe administration of anticoagulants is paramount, regardless of CHA2DS2-VASc score.
Conclusions:
- Anticoagulant therapy should be administered to CA patients with AF, independent of their CHA2DS2-VASc score.
- A multidisciplinary approach is vital for managing CA, optimizing treatment, and minimizing risks such as bleeding and drug interactions.
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