Prognostic Impact of Perioperative CA125 Status in Gastric Cancer Based on New Cutoff Values
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View abstract on PubMed
Summary
This summary is machine-generated.New cutoff values for carbohydrate antigen 125 (CA125) in gastric cancer reveal high preoperative CA125 predicts noncurative resection and poor prognosis. Postoperative CA125 also indicates potential recurrence risk.
Area Of Science
- Oncology
- Clinical Chemistry
Background
- The current carbohydrate antigen 125 (CA125) cutoff shows high specificity but low sensitivity for gastric cancer.
- Evaluating perioperative CA125 with new cutoff values is crucial for improving prognostic accuracy.
Purpose Of The Study
- To assess the clinical impact of perioperative CA125 using novel cutoff values in gastric cancer patients.
- To determine if CA125 levels predict resection status and overall survival.
Main Methods
- Retrospective analysis of 525 gastric cancer patients (2011-2020).
- Utilized receiver operating characteristic curves to establish preoperative (15.7 IU/mL) and postoperative (17.3 IU/mL) CA125 cutoff values.
- Multivariate analysis examined the prognostic impact of CA125 levels and their changes.
Main Results
- Preoperative CA125 positivity was 25%, higher in males, advanced TNM stages, and noncurative resections.
- Preoperative CA125 positivity significantly correlated with higher noncurative resection rates (32% vs. 10%).
- Preoperative CA125 positivity was an independent poor prognostic factor; postoperative levels at 3 months also indicated poor prognosis.
Conclusions
- High preoperative CA125 (>15.7 IU/mL) is a significant predictor of noncurative resection and poor prognosis in gastric cancer.
- Postoperative CA125 positivity at three months serves as a potential predictor for recurrence and adverse outcomes.
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