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Updated: Jul 13, 2026

Transplantation into the Anterior Chamber of the Eye for Longitudinal, Non-invasive In vivo Imaging with Single-cell Resolution in Real-time
Published on: March 10, 2013
Visual restoration with KPro after face allotransplantation with a grade III phthisical eye
Dinasha N Dahanayake1, Alexandra G Castillejos1, James Chodosh1
1Retina Service and Cornea Service, Department of Ophthalmology, Mass Eye and Ear, Mass General Brigham Harvard Medical School, Boston, Massachusetts.
Abstract:
The Boston Keratoprosthesis type I (KPro-I) has been shown to be successful in restoring vision after severe ocular burns; however, its long-term outcomes in phthisical eyes have rarely been reported. A monocular woman with a history of severe alkali chemical injury necessitating facial transplantation presented with a light perception left eye after a complicated course, including failed KPro-I, therapeutic penetrating keratoplasty, endophthalmitis, hypotony, total retinal detachment, and structural changes, including a shrunken 18 mm axial length and eye wall thickening. The patient underwent a combined vitrectomy with silicone oil and KPro-I implantation, resulting in her regaining ambulatory visual acuity (20/250) at 3 years' follow-up.
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