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Related Concept Videos

  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Impact Of Ovariectomy On Neurotransmitter Receptors Bdnf/trkb And Endoplasmic Reticulum Molecular Chaperones In Rat Hypoglossal Nucleus.
  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Impact Of Ovariectomy On Neurotransmitter Receptors Bdnf/trkb And Endoplasmic Reticulum Molecular Chaperones In Rat Hypoglossal Nucleus.

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    Impact of ovariectomy on neurotransmitter receptors BDNF/TrkB and endoplasmic reticulum molecular chaperones in rat hypoglossal nucleus.

    Huan Lu1,2, Qinhan Wu2, Zilong Liu2

    • 1Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

    Sleep and Biological Rhythms
    |July 4, 2024

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Ovariectomy in rats reduced key receptors in the hypoglossal nucleus, increasing motor neuron apoptosis and disrupting ER homeostasis. Estrogen replacement partially restored these functions, suggesting a role in female obstructive sleep apnea pathogenesis.

    Keywords:
    Endoplasmic reticulum molecular chaperonesHypoglossal nucleusNeurotransmitter receptorsObstructive sleep apneaOvariectomy

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    Area of Science:

    • Neuroscience
    • Endocrinology
    • Sleep Medicine

    Background:

    • Obstructive sleep apnea (OSA) pathogenesis research primarily focuses on the hypoglossal nerve-genioglossus axis.
    • Changes in OSA incidence around menopause require further clarification.
    • The impact of ovariectomy on hypoglossal motoneurons is not well understood.

    Purpose of the Study:

    • To investigate the effects of ovariectomy on neurotransmitter receptor expression in the rat hypoglossal nucleus.
    • To explore the involvement of BDNF/TrkB signaling and endoplasmic reticulum chaperones in ovariectomized rats.
    • To assess the potential of estrogen replacement therapy for menopausal OSA.

    Main Methods:

    • Utilized a rat ovariectomy model.
    • Evaluated expression changes of 5-HT2A and α1-Adrenergic receptors in the hypoglossal nucleus.
    • Assessed hypoglossal motor neuron apoptosis, BDNF/TrkB signaling, and endoplasmic reticulum molecular chaperones (UPR, CANX-CALR cycle).

    Main Results:

    • Ovariectomized rats showed significantly reduced 5-HT2A and α1-Adrenergic receptor expression.
    • Increased apoptosis of hypoglossal motor neurons was observed in ovariectomized rats.
    • BDNF expression was upregulated, TrkB downregulated, UPR activated, and the CANX-CALR cycle disrupted, with partial restoration by estrogen replacement.

    Conclusions:

    • Estrogen deficiency impacts hypoglossal nucleus function, neurotransmitter receptor expression, BDNF/TrkB signaling, and ER homeostasis.
    • These changes may contribute to the pathogenesis of OSA in menopausal women.
    • Estrogen therapy presents a potential therapeutic avenue for female OSA.