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A Foldaxane-Based Supramolecular Muscle-Like Switch.

Philip Waelès¹, Frédéric Coutrot¹

¹Supramolecular Machines and Architectures Team, IBMM, Université de Montpellier, CNRS, ENSCM, Montpellier, France.

|July 4, 2024

Summary

This summary is machine-generated.

Researchers developed a novel foldamer-containing switch mimicking muscle function. This supramolecular assembly can transition between contracted and stretched states upon chemical stimulus, offering new possibilities for molecular machines.

Keywords:

daisy chain foldaxane molecular muscle supramolecular template

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Area of Science:

Supramolecular Chemistry
Materials Science
Chemical Engineering

Background:

Daisy chain molecular muscle architectures are self-assemblies of hermaphrodite monomers.
These structures feature a macrocycle linked to a molecular thread with interaction sites (molecular stations).
Controlled alteration of affinity between macrocycles and stations enables molecular contraction and extension, mimicking muscle operation.

Purpose of the Study:

To explore the underexplored field of combining helix and template-containing rods for foldamer supramolecular assemblies.
To report the first supramolecular muscle-like foldamer-containing switch.
To demonstrate stimulus-responsive conformational changes in foldamer-based systems.

Main Methods:

Utilizing foldamer units as surrogates for macrocycles in supramolecular assembly.
Designing a molecular switch incorporating foldamer units and molecular threads.
Applying chemical stimulus to induce conformational changes.

Main Results:

The developed foldamer-containing switch successfully mimics muscle-like contraction and extension.
The system can adopt a contracted co-conformational state after chemical stimulus.
A degenerate-like state was observed, characterized by slow exchange between contracted and stretched states.

Conclusions:

Foldamer units can effectively serve as macrocycle surrogates in supramolecular muscle architectures.
The novel foldamer-containing switch demonstrates controllable, stimulus-responsive conformational changes.
This work opens new avenues for designing advanced molecular machines and soft materials.