Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

373
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
373
Equilibrium and Balance01:15

Equilibrium and Balance

4.7K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
4.7K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

9.2K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glymphatic function restored by α1-noradrenergic antagonism alleviates headache allodynia in mice.

bioRxiv : the preprint server for biology·2026
Same author

Advances in CGRP therapeutic targets for migraine: where do we stand 5 years later?

Expert opinion on therapeutic targets·2026
Same author

The effects of elevated CO<sub>2</sub> on brain and ocular signal intensity with intravenous contrast MRI.

Journal of neurophysiology·2026
Same author

Dynamic MRI of Fluid and Solute Transportation across the Arachnoid Barrier in the Human Meninges.

Radiology·2026
Same author

The glymphatic system clears amyloid beta and tau from brain to plasma in humans.

Nature communications·2026
Same author

Overlapping pathways of migraine and the endocannabinoid system: Potential therapeutic targets.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
See all related articles

Related Experiment Video

Updated: Jun 22, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.2K

A new path to migraine.

Andrew F Russo1,2, Jeffrey J Iliff3,4,5

  • 1Department of Molecular Physiology and Biophysics, Department of Neurology, University of Iowa, Iowa City, IA, USA.

Science (New York, N.Y.)
|July 4, 2024
PubMed
Summary
This summary is machine-generated.

Cerebrospinal fluid entering the brain directly activates trigeminal neurons, a key pathway in migraine pain. This finding reveals a novel mechanism contributing to migraine headaches.

More Related Videos

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

767
Investigating Migraine-Like Behavior Using Light Aversion in Mice
05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

3.8K

Related Experiment Videos

Last Updated: Jun 22, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.2K
Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

767
Investigating Migraine-Like Behavior Using Light Aversion in Mice
05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

3.8K

Area of Science:

  • Neuroscience
  • Pain research
  • Cerebrovascular biology

Background:

  • Migraine is a debilitating neurological disorder characterized by severe head pain.
  • The trigeminovascular system is critically involved in migraine pathophysiology.
  • The precise mechanisms by which migraine triggers activate trigeminal neurons are not fully understood.

Purpose of the Study:

  • To investigate whether cerebrospinal fluid (CSF) influx into cranial tissues directly activates trigeminal neurons.
  • To elucidate the role of CSF in trigeminal nerve activation during a migraine model.

Main Methods:

  • Utilized a preclinical migraine model in rodents.
  • Employed in vivo calcium imaging to monitor trigeminal neuron activity.
  • Assessed the effects of induced cerebrospinal fluid influx on neuronal activation.

Main Results:

  • Direct influx of cerebrospinal fluid into perivascular spaces was observed.
  • Cerebrospinal fluid influx significantly increased the activity of trigeminal neurons.
  • Pharmacological inhibition of CSF leakage reduced trigeminal neuron activation.

Conclusions:

  • Cerebrospinal fluid influx serves as a direct trigger for trigeminal neuron activation in a migraine model.
  • This mechanism provides a novel target for understanding and potentially treating migraine pain.
  • Findings highlight the importance of the brain-fluid interface in pain signaling.