Related Experiment Video
Updated: Jun 22, 2025
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
27.9K
The hidden link: How oral and respiratory microbiomes affect multiple sclerosis
Melika Jameie1, Bahareh Ahli2, Sara Ghadir3
1Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran; Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Multiple Sclerosis and Related Disorders
|July 4, 2024
Summary
Altered oral and respiratory microbiomes are linked to multiple sclerosis (MS). Specific bacteria changes in the mouth and nose may influence MS risk and symptoms, suggesting new therapeutic avenues.
Area of Science:
- Microbiology
- Immunology
- Neurology
Background:
- Gut microbiota research in multiple sclerosis (MS) is extensive.
- The role of oral and respiratory tract microbial communities in MS is an emerging area.
Purpose of the Study:
- To review current literature on nasal, oral, and lung microbiota in people with MS (PwMS).
Main Methods:
- Conducted a narrative review of original studies on PubMed.
- Searched for relevant studies in reference lists of reviews and included studies.
Main Results:
- Thirteen studies reviewed: 8 on oral, 3 on nasal, 2 on lung microbiota.
- Significant alterations in oral and respiratory microbiomes of PwMS compared to healthy controls (HCs).
- Specific bacterial genera (e.g., Staphylococcus, Fusobacterium) were more abundant in PwMS, while others (e.g., Aggregatibacter, Streptococcus) were less abundant.
Conclusions:
- Oral and nasal microbiome alterations in PwMS may influence MS pathogenesis (e.g., Epstein-Barr virus reactivation, S. aureus toxins).
- Lung microbiome modulation in animal models showed potential for suppressing MS symptoms.
- Further research is crucial to understand microbiome-MS interactions for therapeutic development.
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