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Related Concept Videos

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The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
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Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
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Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging
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Embryonically active piriform cortex neurons promote intracortical recurrent connectivity during development.

David C Wang1, Fernando Santos-Valencia2, Jun H Song3

  • 1Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA 94305, USA; Stanford MSTP, Stanford, CA 94305, USA.

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|July 4, 2024
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Summary

Early neuronal activity shapes brain circuits. In mice, active piriform cortex neurons identified via targeted recombination in active populations (TRAP) promote synaptic connections during development.

Keywords:
FosNeuropixels recordingTRAP2activity-dependent wiringembryonic activityhub-like populationpiriform cortexrecurrent networksynchronized population activitywhole-cell recording

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Systems Neuroscience

Background:

  • Neuronal activity is crucial for brain circuit maturation.
  • The role of early activity in regulating circuit development across the brain is not fully understood.

Purpose of the Study:

  • To conduct a brain-wide survey of prenatal neuronal activity using targeted recombination in active populations (TRAP) in mice.
  • To investigate the role of identified active neurons in circuit maturation.

Main Methods:

  • Utilized targeted recombination in active populations (TRAP) for brain-wide identification of prenatal activity.
  • Performed whole-cell recordings in neonatal slices and in vivo Neuropixels recordings.
  • Manipulated activity of identified neurons in neonates.

Main Results:

  • Identified the piriform cortex as a region with abundant prenatal activity (TRAPed neurons).
  • Embryonically TRAPed piriform neurons showed preferential interconnectivity and enhanced synaptic connectivity.
  • These neurons led spontaneous synchronized population activity and their manipulation affected recurrent synaptic strength.

Conclusions:

  • Embryonically TRAPed piriform neurons form an interconnected hub.
  • Activity of these piriform neurons promotes recurrent connectivity during early development.