Effects of dietary 5-aminolevulinic acid on growth performance and nonspecific immunity of Litopenaeus vannamei, as determined by transcriptomic analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Dietary 5-aminolevulinic acid (5-ALA) enhances growth and immunity in shrimp (Litopenaeus vannamei). Supplementation improved survival, growth rates, and immune responses, with an optimal dose identified for aquaculture applications.
Area Of Science
- Aquaculture
- Animal Nutrition
- Immunology
Background
- 5-aminolevulinic acid (5-ALA) is an endogenous amino acid utilized in agriculture.
- Understanding its impact on aquatic species like shrimp is crucial for optimizing aquaculture practices.
Purpose Of The Study
- To investigate the effects of dietary 5-ALA on the growth performance and nonspecific immunity of Litopenaeus vannamei.
- To determine the optimal dietary concentration of 5-ALA for shrimp.
Main Methods
- Shrimp were fed diets supplemented with 5-ALA at varying concentrations (0-60 mg/kg) for three months.
- Transcriptome sequencing and qRT-PCR were used to analyze gene expression related to immunity and growth.
- Key immune parameters and growth metrics were measured.
Main Results
- Dietary 5-ALA significantly improved survival rates, body length, and weight gain, with the highest values at 45 mg/kg.
- Immune parameters such as hemocyte count, phagocytosis, and antioxidant enzyme activities were enhanced.
- Transcriptome analysis revealed up-regulation of antioxidant and immune-related genes.
Conclusions
- Dietary 5-ALA positively influences the growth and nonspecific immunity of Litopenaeus vannamei.
- The optimal dietary 5-ALA concentration for shrimp was determined to be 39.43 mg/kg.
- 5-ALA shows potential as a valuable dietary supplement in shrimp aquaculture.
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