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Abnormal static and dynamic brain network connectivity associated with chronic tinnitus.

Jiapei Xie1, Weidong Zhang2, Chen Yu1

  • 1Department of Medical Imaging, The People's Hospital of Zhengzhou University & Henan Provincial People's Hospital, Zhengzhou, China.

Neuroscience
|July 4, 2024
PubMed
Summary

Chronic tinnitus alters brain network connectivity, affecting auditory, default mode, attention, and sensorimotor networks. These changes offer insights into tinnitus mechanisms and potential treatments.

Keywords:
Brain networkDynamic FNCStatic FNCTinnitusrs-fMRI

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Systems Biology

Background:

  • Chronic tinnitus is a complex auditory disorder characterized by the perception of sound without an external source.
  • Understanding the neural underpinnings of chronic tinnitus is crucial for developing effective therapeutic strategies.

Purpose of the Study:

  • To investigate alterations in brain network connectivity in patients with chronic tinnitus using both static and dynamic functional network connectivity (FNC) analyses.
  • To explore the temporal dynamics of brain networks and their relationship with tinnitus severity and duration.

Main Methods:

  • Recruited 32 patients with chronic tinnitus and 30 healthy controls (HC).
  • Utilized independent component analysis (ICA) to identify resting-state networks (RSNs).
  • Performed static and dynamic FNC analyses, calculating temporal properties like mean dwell time (MDT), fraction time (FT), and number of transitions (NT).

Main Results:

  • Four RSNs (auditory, default mode, attention, sensorimotor) exhibited abnormal FNC in tinnitus patients.
  • Static analysis revealed decreased FNC between several networks (AUN-DMN, AUN-AN, DMN-AN, DMN-SMN) in tinnitus patients compared to HC.
  • Dynamic analysis showed decreased FNC in the DMN-AN in state 3, with significantly reduced MDT in state 3 for tinnitus patients.
  • Tinnitus severity (TFI score) negatively correlated with MDT and FT in state 4; tinnitus duration positively correlated with FT in state 1 and NT.

Conclusions:

  • Chronic tinnitus is associated with significant abnormalities in static and dynamic brain network connectivity.
  • These findings elucidate the neural mechanisms underlying tinnitus generation and chronicity.
  • The identified network alterations provide a potential basis for novel tinnitus treatment approaches.