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  11. Identification Of Peripheral Blood Test Parameters Predicting The Response To Palbociclib And Endocrine Therapy For Metastatic Breast Cancer: A Retrospective Study In A Single Institution

Identification of peripheral blood test parameters predicting the response to palbociclib and endocrine therapy for metastatic breast cancer: a retrospective study in a single institution

Misato Yamamoto1, Masahiro Shibata2,3, Aya Tanaka1,4

  • 1Department of Breast and Endocrine Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan.

Surgery Today
|July 4, 2024

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Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
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View abstract on PubMed

Summary
This summary is machine-generated.

Blood tests can predict how well patients with metastatic breast cancer respond to palbociclib and endocrine therapy. High lactate dehydrogenase (LDH) and low albumin (Alb) levels indicate shorter progression-free survival (PFS).

Area of Science:

  • Oncology
  • Medical Diagnostics
  • Pharmacology

Background:

  • Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors combined with endocrine therapy improve progression-free survival (PFS) in ER-positive, HER2-negative metastatic breast cancer.
  • Predictors of treatment efficacy for CDK4/6 inhibitors remain largely unknown.

Purpose of the Study:

  • To identify peripheral blood test parameters that predict the efficacy of palbociclib plus endocrine therapy.
  • To investigate potential biomarkers for treatment response in metastatic breast cancer.

Main Methods:

  • Retrospective review of 79 patients with ER-positive, HER2-negative metastatic breast cancer treated with palbociclib and endocrine therapy.
  • Assessment of progression-free survival (PFS) based on patient characteristics and peripheral blood test results, including C-reactive protein (CRP), lactate dehydrogenase (LDH), and albumin (Alb).
Keywords:
AlbuminBreast cancerC-reactive proteinLactate dehydrogenase

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Main Results:

  • Elevated CRP, elevated LDH, and low Alb levels were associated with significantly shorter PFS.
  • Multivariate analysis identified high LDH and low Alb as independent predictors of PFS.
  • Low albumin levels correlated with inferior disease control rates.

Conclusions:

  • Peripheral blood parameters, specifically LDH and Alb levels, can predict treatment efficacy in patients receiving palbociclib and endocrine therapy.
  • These findings may aid in personalizing treatment strategies for ER-positive, HER2-negative metastatic breast cancer.
Palbociclib