Correlation between controlled attenuation parameter values with SYNTAX score in patients with significant coronary...

Area of Science:

• Cardiology
• Hepatology
• Medical Imaging

Background:

• Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease.
• Coronary artery disease (CAD) is the primary cause of mortality in NAFLD patients.
• The relationship between liver steatosis severity and coronary atherosclerosis is not well understood.

Purpose of the Study:

• To investigate the correlation between controlled attenuation parameter (CAP) values and SYNTAX scores in adult patients with significant CAD.
• To assess liver steatosis severity using CAP and its association with coronary atherosclerosis burden.

Main Methods:

• A cross-sectional study involving 124 adult patients with significant CAD who underwent coronary angiography.
• Transient elastography with CAP was utilized to quantify liver steatosis.
• SYNTAX scores were calculated to evaluate coronary atherosclerosis severity.

Main Results:

• A significant positive correlation was found between CAP values and SYNTAX scores (r=0.245, p<0.0001).
• The correlation was stronger in patients with a history of percutaneous coronary intervention (PCI) (r=0.389, p=0.037).
• Patients with high-risk SYNTAX scores (>32) exhibited significantly higher CAP values compared to low-risk patients (p=0.006).

Conclusions:

• Liver steatosis severity, measured by CAP, is significantly correlated with the extent of coronary atherosclerosis in patients with significant CAD.
• Patients with NAFLD, particularly those with severe steatosis, require regular cardiovascular assessment and lifestyle interventions.
• This study highlights the importance of considering liver health in the management of cardiovascular disease.