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Updated: Jun 22, 2025

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Programming tumor evolution with selection gene drives to proactively combat drug resistance

Scott M Leighow1,2, Joshua A Reynolds1, Ivan Sokirniy1,2

  • 1Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.

Nature Biotechnology
|July 4, 2024
PubMed
Summary

This study introduces selection gene drives to redirect tumor evolution and overcome drug resistance. These engineered systems effectively eliminate diverse cancer resistance mechanisms in vitro and in vivo.

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