Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dietary immunostimulation: interaction with BCG and LPS.

R Pageau, R Lallier

    Experientia
    |November 15, 1979
    PubMed
    Summary

    The timing of administering Bacillus Calmette-Guérin (BCG) and lipopolysaccharide (LPS) with a specific diet impacts immune responses. These substances act as interacting adjuvants, influencing various immune system components.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dose-response effects of TPI ASM8 in asthmatics after allergen.

    Allergy·2011
    Same author

    Development of an indirect enzyme-linked immunosorbent assay for the detection of leptospiral antibodies in dogs.

    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2000
    Same author

    A sandwich enzyme-linked immunosorbent assay for the detection of Streptococcus suis.

    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·1993
    Same author

    Biochemical characterization of an antigenic saline extract of Actinobacillus pleuropneumoniae serotype 5 and identification of a serotype-specific antigen for ELISA serodiagnosis.

    Veterinary microbiology·1992
    Same author

    Production and purification of heat-stable enterotoxin b from a porcine Escherichia coli strain.

    Infection and immunity·1991
    Same author

    Purification, and biochemical and structural characterization of a fimbrial haemagglutinin of Renibacterium salmoninarum.

    Journal of general microbiology·1990

    Area of Science:

    • Immunology
    • Microbiology
    • Nutrition Science

    Background:

    • Bacillus Calmette-Guérin (BCG) and lipopolysaccharide (LPS) are known immunomodulators.
    • Dietary components can significantly influence immune system function and vaccine efficacy.
    • Understanding adjuvant interactions is crucial for optimizing immune stimulation.

    Purpose of the Study:

    • To investigate the combined effects of BCG and LPS mR595 administration with a formula-defined diet.
    • To determine the role of administration timing on the immune response elicited by BCG and LPS mR595.
    • To characterize the adjuvant-like properties and interactions of BCG and LPS mR595 in a controlled dietary setting.

    Main Methods:

    • Administration of BCG and LPS mR595 to study subjects on a formula-defined diet.
    • Varying the timing of BCG and LPS mR595 administration.
    • Analysis of immune system components and responses.
    • Assessment of adjuvant activity and interactions.

    Main Results:

    • The immune effects of BCG and LPS mR595 are significantly influenced by the timing of their administration.
    • The combination of BCG, LPS mR595, and the diet exhibits properties of interacting adjuvants.
    • Different elements of the immune system are differentially affected based on administration timing.

    Conclusions:

    • Administration timing is a critical factor in the immunomodulatory action of BCG and LPS mR595.
    • BCG and LPS mR595 function as interacting adjuvants, modulating the immune system in a time-dependent manner.
    • Further research into adjuvant timing and dietary interactions can inform the development of enhanced immunotherapies and vaccines.

    Related Experiment Videos