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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Outcome Comparison in Hospitalized COVID-19 Patients With and Without AKI
Sanjivani Shrestha1, Yani Zhang2, Wajehe Najafi2
1Department of Nephrology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Summary
Hospitalized COVID-19 patients with Acute Kidney Injury (AKI) faced significantly higher in-patient mortality and critical care needs. This study highlights the severe impact of AKI on COVID-19 outcomes, particularly in a predominantly Black patient population.
Area of Science:
- Nephrology
- Infectious Diseases
- Critical Care Medicine
Background:
- Hospitalized patients with COVID-19 exhibit a higher incidence of Acute Kidney Injury (AKI) compared to non-COVID patients.
- Previous research indicates a significant association between AKI and increased mortality rates in COVID-19 patients.
Purpose of the Study:
- To investigate the outcomes of COVID-19-associated AKI in a predominantly Black patient population.
- To compare outcomes between COVID-19 patients with and without AKI during hospitalization.
Main Methods:
- Retrospective cohort study of 1107 adult patients admitted with symptomatic COVID-19.
- Data collected from 9 acute care facilities within the MedStar Health system.
- Follow-up extended to 3 months post-discharge, analyzing inpatient mortality, ICU admission, intubation, and renal function.
Main Results:
- AKI incidence was 35% among hospitalized COVID-19 patients; 74% of AKI patients were African American.
- In-patient mortality was 41.9% in the AKI group versus 9.9% in the non-AKI group.
- COVID-19 patients with AKI had significantly higher risks of mortality (OR 4.71), ICU admission (OR 4.27), and intubation (OR 6.18).
Conclusions:
- Acute Kidney Injury in hospitalized COVID-19 patients is strongly linked to increased mortality.
- AKI is associated with a greater need for intensive care unit admission and mechanical ventilation.
- These findings underscore the critical impact of AKI on COVID-19 patient outcomes.
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