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The efficacy and tolerance of indapamide in essential hypertension: a multi-centre study in 981 patients
Insights
Indapamide effectively treated essential hypertension in 981 patients, significantly lowering blood pressure. This study highlights indapamide
Area of Science:
- Cardiology
- Pharmacology
- Clinical Trials
Background:
- Essential hypertension affects a significant portion of the adult population.
- Effective and well-tolerated antihypertensive medications are crucial for managing hypertension.
- Indapamide is a diuretic commonly prescribed for hypertension.
Purpose of the Study:
- To evaluate the efficacy and tolerance of indapamide in treating essential hypertension.
- To assess the impact of indapamide on blood pressure levels and serum potassium.
- To determine the clinical acceptability of indapamide treatment.
Main Methods:
- A multi-centre open trial involving 150 cardiologists and 981 patients with essential hypertension.
- Patients received 2.5 mg of indapamide daily for 4 months.
- Blood pressure, serum potassium, and clinical acceptability were monitored at regular intervals.
Main Results:
- Mean blood pressure decreased from 179/103 mmHg to 150/86 mmHg after 16 weeks of treatment.
- Normal blood pressure levels were achieved in 80% of patients with indapamide monotherapy.
- Clinical acceptability was rated as good or excellent in 89% of cases with minimal side effects.
Conclusions:
- Indapamide is an effective and well-tolerated treatment for essential hypertension.
- Indapamide monotherapy can normalize blood pressure in a majority of hypertensive patients.
- The study supports the use of indapamide as a first-line antihypertensive agent.
Abstract:
A multi-centre open trial involving 150 cardiologists throughout France was undertaken to assess the efficacy and tolerance of indapamide in the treatment of essential hypertension. An identical protocol was used by all of the cardiologists. A total of 981 patients (mean age 58 years) was included in the trial after an observation period of 1 month during which blood pressure was recorded regularly. Patients were included if they had permanent essential hypertension with a diastolic pressure of 95 mmHg or more. Mean systolic and diastolic blood pressures at the end of the initial observation period were 179/103 mmHg. The treatment period lasted for 4 months during which the patients received 1 tablet of indapamide (2.5 mg) each morning. Blood pressure was measured after 6 and 16 weeks of treatment, and clinical and biological acceptability was also assessed. After 6 weeks of treatment, mean systolic and diastolic blood pressure levels decreased to 158/90 mmHg: after 16 weeks these mean figures were 150/86 mmHg. Blood pressure levels became normal with indapamide treatment alone in 80% of patients. A slight decrease in serum potassium levels was noted in the first 6 weeks of treatment and then became stable. Clinical acceptability was considered good or excellent in 89% of cases and few non-specific side-effects were reported.