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In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function
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Durable response to nivolumab rechallenge in a patient with metastatic clear cell renal cell carcinoma

Motohiro Fujiwara1, Wataru Shimada1, Minato Yokoyama1

  • 1Department of Urology Tokyo Medical and Dental University Tokyo Japan.

IJU Case Reports
|July 5, 2024
PubMed
Abstract

Insights

Nivolumab rechallenge may benefit some patients with metastatic renal cell carcinoma (mRCC) when standard treatments fail. This case study explores a durable response to nivolumab rechallenge in advanced mRCC.

Area of Science:

  • Oncology
  • Immunotherapy
  • Renal Cell Carcinoma Research

Background:

  • Immune checkpoint inhibitors are standard for metastatic renal cell carcinoma (mRCC).
  • A clear treatment strategy after immune checkpoint inhibitors is lacking.
  • This report details a unique case of mRCC management.

Observation:

  • A 60-year-old male with metastatic melanoma received nivolumab.
  • He was diagnosed with clear cell renal cell carcinoma (ccRCC) post-nephrectomy.
  • Despite multiple therapies, his mRCC progressed.

Findings:

  • Nivolumab rechallenge was initiated along with palliative radiotherapy.
  • The patient achieved a durable response lasting 20 months.
  • This is the first reported instance of nivolumab rechallenge in mRCC.

Implications:

  • Nivolumab rechallenge might offer a therapeutic option for select mRCC patients.
  • Further investigation is needed to establish the utility of nivolumab rechallenge.
  • This case contributes to understanding treatment sequencing in advanced mRCC.
Keywords:
clear cell renal cell carcinomaimmune checkpoint inhibitorsnivolumabnivolumab rechallenge

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