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Related Experiment Video

Updated: Jun 22, 2025

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
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Diverse Chiral Nanotubes Assembled from Identical DNA Strands.

Chun Xie1, Zhekun Chen1, Kuiting Chen1

  • 1Key Laboratory of Image Information Processing and Intelligent Control of Education Ministry of China, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, 430074 Hubei, China.

Nano Letters
|July 5, 2024
PubMed
Summary

This study introduces a novel DNA nanotube assembly method using intercalators. This technique allows for diverse DNA nanotube widths and chirality from identical DNA strands, reducing costs and labor.

Keywords:
DNA nanotechnologychiralityintercalationnanotubeself-assembly

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Area of Science:

  • Nanotechnology
  • Biomaterials Science
  • Synthetic Biology

Background:

  • DNA nanotubes offer versatile applications due to their controllable geometries.
  • Current methods for creating DNA nanotubes with specific widths or chirality are often expensive and time-consuming, requiring custom DNA sequence synthesis.

Purpose of the Study:

  • To develop a cost-effective and versatile method for producing DNA nanotubes with tunable widths and chirality.
  • To demonstrate the use of intercalators to control DNA tile assembly and nanotube formation.

Main Methods:

  • An intercalator-assisted DNA tile assembly approach was employed.
  • The concentration of intercalators was adjusted to modulate the twisting direction and extent of DNA tiles.
  • Secondary annealing with additional intercalators was used to reconfigure nanotube chirality.

Main Results:

  • The proposed method enables the production of DNA nanotubes with diverse widths and chirality using identical DNA strands.
  • Intercalator concentration directly influences the controllable formation of DNA nanotubes.
  • Right-handed nanotubes can be successfully converted into left-handed ones.

Conclusions:

  • The intercalator-assisted assembly method provides a universal platform for modulating DNA tile self-assembly pathways.
  • This approach simplifies the production of complex DNA nanostructures, reducing costs and effort.
  • The findings have broad implications for DNA tile assembly and the development of other chiral materials.