Gut microbiota-lncRNA/circRNA crosstalk: implications for different diseases

Area of Science:

• Microbiology
• Molecular Biology
• Genetics

Background:

• The gut microbiota is crucial for human physiology and metabolic homeostasis.
• Microbial imbalance (dysbiosis) is linked to various diseases.
• Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are key regulators in cellular processes.

Purpose of the Study:

• To review the interaction between gut microbiota and lncRNAs/circRNAs.
• To investigate the role of this crosstalk in disease pathogenesis.
• To highlight the clinical value of this interaction.

Main Methods:

• Literature review of existing research on gut microbiota, lncRNAs, and circRNAs.
• Analysis of studies detailing the regulatory mechanisms involved.
• Synthesis of findings related to disease development and progression.

Main Results:

• Gut microbiota targets specific lncRNAs (e.g., ENO1-IT1, BFAL1, LINC00152) to regulate colorectal cancer.
• Gut microbiota modulates circRNAs (e.g., circNF1-419, circHIPK2) impacting mental diseases and lung tumor metastasis.
• Evidence supports a significant role for microbiota-RNA crosstalk in various pathologies.

Conclusions:

• The interaction between gut microbiota and lncRNAs/circRNAs is a critical factor in disease development.
• Understanding this crosstalk provides a theoretical basis for novel therapeutic approaches.
• Targeting the gut microbiota-lncRNA/circRNA axis holds significant clinical potential.