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Updated: Jun 22, 2025

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Neuronal Stability, Volumetric Changes, and Decrease in GFAP Expression of Marmoset (Callithrix jacchus) Subcortical

Nelyane N M Santana1, Eryck H A Silva2, Sâmarah F Dos Santos2

  • 1Edmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, Brazil.

The Journal of Comparative Neurology
|July 5, 2024
PubMed
Summary
This summary is machine-generated.

Aging affects the brain

Keywords:
agingdorsal lateral geniculate nucleusmarmosetsoptical densitystereologysuperior colliculus

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Area of Science:

  • Neuroscience
  • Aging Research
  • Visual System Anatomy

Background:

  • Physiological aging causes visual decline.
  • The dorsal lateral geniculate nucleus (DLG) and superior colliculus (SC) are key visual pathway structures.
  • Limited quantitative data exist on DLG and SC aging.

Purpose of the Study:

  • Investigate age-related morphological and neurochemical changes in marmoset DLG and SC.
  • Quantify neuronal number, volume, and glial fibrillary acidic protein (GFAP) immunoexpression across the lifespan.
  • Determine region-specific aging patterns in these visual centers.

Main Methods:

  • Used optical density for GFAP immunoexpression.
  • Employed stereological probes to estimate neuronal number and volume in DLG and SC.
  • Studied marmosets aged 36 to 143 months.

Main Results:

  • DLG showed age-related increases in total and layer volume; SC volume remained stable.
  • Neuronal number was stable in DLG and superficial SC (SCv).
  • GFAP immunoexpression decreased in both DLG and SC, suggesting astroglial atrophy.

Conclusions:

  • DLG and SCv exhibit resilience in neuronal number during aging.
  • Region-specific volumetric changes in DLG may involve plasticity and compensatory mechanisms.
  • Reduced GFAP indicates potential morphological changes in glial cells, impacting visual perception.