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Relationship between angiogenesis biomarker endocan and apolipoproteins in patients with acute myocardial infarction
Mehdi Hassanpour1,2, Reza Rahbarghazi3,4, Aysa Rezabakhsh5
1Department of Clinical Biochemistry and Laboratory Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Insights
High endocan levels indicate endothelial dysfunction and ischemic cardiovascular conditions in ST-elevation myocardial infarction patients. This is significantly correlated with apolipoprotein-B (APO-B), but not apolipoprotein-A1 (APO-A1).
Area of Science:
- Cardiovascular Medicine
- Biochemistry
- Biomarkers
Background:
- Endocan, a novel endothelial cell-specific molecule, is implicated in vascular inflammation.
- Apolipoproteins A-I (APO-A1) and B (APO-B) are key lipid-binding proteins involved in cardiovascular risk.
- Endothelial dysfunction is a critical factor in the pathogenesis of acute myocardial infarction (AMI).
Purpose of the Study:
- To investigate serum endocan levels in patients with ST-elevation myocardial infarction (STEMI).
- To assess the correlation between endocan and apolipoprotein-A1 (APO-A1) and apolipoprotein-B (APO-B) in STEMI patients.
Main Methods:
- Serum levels of endocan, cardiac troponin I (cTnI), APO-A1, and APO-B were measured in 80 male STEMI patients and a control group.
- Statistical analysis was performed to evaluate correlations between endocan, APO-A1, APO-B, and the APO-B/APO-A1 ratio.
Main Results:
- STEMI patients exhibited significant differences in APO-A1, APO-B, endocan levels, and the APO-B/APO-A1 ratio compared to controls (p < 0.05).
- A significant positive correlation was observed between serum endocan and APO-B levels.
- No significant correlation was found between endocan and APO-A1 levels.
Conclusions:
- Elevated serum endocan levels serve as an independent marker for endothelial dysfunction and ischemic cardiovascular conditions.
- The findings suggest a potential link between high endocan levels and APO-B in the context of STEMI.
Abstract:
Aim: In the current study, serum levels of endocan in patients attended with ST-elevation myocardial infarction, as well as the possible correlation with apolipoprotein-A1 (APO-A1) and APO-B were investigated.Materials & methods: In 80 men, endocan, cTnI, APO-A1, and APO-B levels were measured. Finally, the correlation of endocan with APO-A1, APO-B, and APO-B/ APO-A1 ratio was assessed.Results: Significant changes in APO-A1, APO-B, endocan levels, and APO-B/APO-A1 ratio were found in acute myocardial infarction cases compared with the control arm (p < 0.05). In addition, our finding showed a significant correlation between APO-B and endocan levels, but not APO-A.Conclusion: High endocan level is an independent indicator of endothelial dysfunction and ischemic cardiovascular conditions, which could be related to APO-B.
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