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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

11.5K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.5K
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Pathogenesis Mechanism And Potential Clinical Value Of Lncrna In Gliomas.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Pathogenesis Mechanism And Potential Clinical Value Of Lncrna In Gliomas.

Related Experiment Video

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

5.6K

The pathogenesis mechanism and potential clinical value of lncRNA in gliomas.

Yuan Liu1, Hui Yuan1, JingJia Fan1

  • 1Department of Clinical Medicine, School of Clinical Medical, Southwest Medical University, Luzhou, 646000, Sichuan, China.

Discover Oncology
|July 5, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are critical in glioma development and progression. This review details how lncRNA dysregulation impacts glioma, highlighting their clinical significance.

Keywords:
Biological functionDiagnosisGliomaPrognosis

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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

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Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
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Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

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Related Experiment Videos

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

7.9K

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Genetics

Background:

  • Glioma is the most prevalent malignant central nervous system tumor, characterized by poor prognosis.
  • The 2021 World Health Organization classification categorizes gliomas based on histology and molecular features.
  • Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts regulating cellular processes.

Purpose of the Study:

  • To review the role of lncRNA dysregulation in glioma pathogenesis and progression.
  • To explore the impact of lncRNAs on key biological processes in gliomas.
  • To summarize the clinical significance of lncRNAs in glioma management.

Main Methods:

  • Literature review of studies on lncRNA and glioma.
  • Analysis of lncRNA involvement in glioma proliferation, apoptosis, invasion, and migration.
Therapy
lncRNA
  • Examination of lncRNA roles in angiogenesis, immune regulation, glycolysis, stemness, and drug resistance.

    • Main Results:

    • lncRNA dysregulation significantly influences glioma cell proliferation and apoptosis.
    • Altered lncRNA expression affects glioma invasion, migration, and angiogenesis.
    • lncRNAs play crucial roles in glioma-associated immune responses, glycolysis, stemness, and drug resistance.

    Conclusions:

    • lncRNA dysregulation is a critical factor in glioma development and malignancy.
    • Understanding lncRNA functions offers potential therapeutic targets for glioma.
    • lncRNAs hold significant clinical value for glioma diagnosis and treatment.