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"Rigid-Flexible" Dual-Ferrocene Chimeric Nanonetwork for Simultaneous Tumor-Targeted Tracing and

Sixue Wang1, Rui Zhang1, Xianqiang Li1

  • 1School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, P. R. China.

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|July 5, 2024
PubMed
Summary

Researchers developed a new nanonetwork, ICG@HFFC, to improve cancer phototherapy. This system enhances the photostability and fluorescence of indocyanine green (ICG), enabling better tumor imaging and treatment efficacy.

Keywords:
aggregation-caused quenching (ACQ)ferrocene (Fc)indocyanine green (ICG)rigid-flexibletumor visualization therapy

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Phototherapy requires agents with real-time imaging for precision cancer treatment.
  • Near-infrared (NIR) fluorescent dyes are crucial for theranostics, but aggregation-caused quenching (ACQ) limits photostability and fluorescence.
  • Indocyanine green (ICG) is the only FDA-approved NIR dye, yet faces challenges with photobleaching and fluorescence retention.

Purpose of the Study:

  • To develop a novel nanonetwork delivery system for indocyanine green (ICG) to overcome limitations of ACQ dyes.
  • To enhance photostability and fluorescence imaging capabilities of ICG for improved cancer theranostics.
  • To create a dual-ferrocene (Fc) chimeric nanonetwork (ICG@HFFC) using a rigid-flexible strategy.

Main Methods:

  • One-step self-assembly of a dual-ferrocene (Fc) chimeric nanonetwork (ICG@HFFC) using Fc-modified hyaluronic acid (HA-Fc) and Fc-octadecylamine (Fc-C18).
  • Utilized rigid Fc interactions for ICG binding and photostability, and flexible alkyl chains for fluorescence preservation.
  • Incorporated HA-Fc for CD44 receptor targeting on tumor cells.

Main Results:

  • ICG@HFFC demonstrated significantly improved photobleaching resistance and enhanced fluorescence stability compared to free ICG.
  • The nanonetwork showed increased singlet oxygen (1O2) production efficiency, crucial for photodynamic therapy.
  • In vivo studies confirmed good tumor tracing ability, significant tumor inhibition, and favorable biocompatibility.

Conclusions:

  • ICG@HFFC offers a promising strategy for simultaneous enhanced tumor tracing and combined photothermal/photodynamic therapy (PTT/PDT).
  • The developed nanonetwork effectively addresses the limitations of ACQ dyes in cancer phototherapy.
  • This approach provides a novel method for precision cancer therapy using theranostic agents.