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Updated: Jun 21, 2025

Measuring Lactase Enzymatic Activity in the Teaching Lab
Published on: August 6, 2018
Reconsidering lactate disallowance in pancreatic β cells
1Diabetes Center of Excellence, University of Massachusetts, Worcester, MA, USA; Program in Molecular Medicine, University of Massachusetts, Worcester, MA, USA.
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Lactate synthesis via lactate dehydrogenase A (LDHA), traditionally considered to be a 'disallowed' function in pancreatic β cells, is redefined by Cuozzo et al. who find that lactate produced by β cells regulates fasting insulin secretion via LDHB. The metabolic sources, fates, and relevance of β cell lactate are further examined.
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