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Blood Pressure Variability After Non-invasive Low-level Tragus Stimulation in Acute Heart Failure
Michiaki Nagai1,2, Keigo Dote3, Masaya Kato3
1Department of Cardiology, Hiroshima City Asa Hospital, Hiroshima, Japan. nagai10m@r6.dion.ne.jp.
Journal of Cardiovascular Translational Research
|July 5, 2024
Summary
Low-level tragus stimulation (LLTS) improved blood pressure variability (BPV) in patients with acute heart failure (AHF). This non-invasive approach reduced BP fluctuations, suggesting a potential new therapy for cardiovascular outcomes in AHF.
Area of Science:
- Cardiology
- Neuromodulation
- Medical Devices
Background:
- Elevated blood pressure variability (BPV) is a significant predictor of adverse cardiovascular outcomes in heart failure (HF).
- The efficacy of low-level tragus stimulation (LLTS) in modulating BPV within the context of acute heart failure (AHF) remains unexplored.
Purpose of the Study:
- To investigate the impact of LLTS on BPV in patients diagnosed with AHF.
- To assess whether LLTS can lead to improvements in blood pressure regulation in this patient population.
Main Methods:
- A randomized, sham-controlled study involving 22 patients with AHF.
- Participants received either active LLTS via an ear clip on the tragus or a sham procedure on the earlobe for 1 hour daily over 5 days.
- Blood pressure variability was assessed using standard deviation (SD), coefficient of variation (CV), and delta (δ) in systolic blood pressure (SBP).
Main Results:
- Active LLTS significantly reduced SD, CV, and δ in SBP in the active group compared to baseline (p < 0.05).
- Significant differences in the changes of SD, CV, and δ in SBP were observed between the active and sham groups (p < 0.05).
Conclusions:
- LLTS demonstrates a beneficial effect on blood pressure variability in patients with acute heart failure.
- This proof-of-concept study suggests LLTS as a potential non-invasive therapeutic strategy for managing BPV in AHF.
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