Related Experiment Video
Updated: Jun 21, 2025

06:31
Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
Published on: October 3, 2019
8.6K
How do physicians respond to new medical research?
Philip DeCicca1, Maripier Isabelle2, Natalie Malak3
1Department of Economics, Ball State University, NBER, Muncie, Indiana, USA.
Health Economics
|July 6, 2024
Summary
When a major medical study on breech birth delivery was overturned, C-section rates decreased significantly, especially for disadvantaged groups. However, this shift did not impact infant health outcomes.
Area of Science:
- Medical research impact
- Obstetrics and Gynecology
- Health policy analysis
Background:
- Prominent medical studies significantly influence clinical practice and physician decision-making.
- The reversal of established medical findings can create uncertainty and necessitate practice adjustments.
- Understanding the impact of study reversals on physician behavior and patient outcomes is crucial for evidence-based medicine.
Purpose of the Study:
- To evaluate the effect of a reversed landmark medical study on physician practices and infant health outcomes.
- To analyze changes in Cesarean section rates following the Term Breech Trial reversal.
- To investigate differential impacts across demographic groups and physician experience levels.
Main Methods:
- Utilized United States Birth Certificate Records from 1995 to 2010.
- Employed a difference-in-differences estimation strategy.
- Focused on Cesarean sections, low Apgar scores, and low birth weight as key outcome measures.
Main Results:
- The reversal of the Term Breech Trial led to a 15%-23% decline in Cesarean sections for breech births, contrasting the rising overall trend.
- The most significant practice changes were observed among non-white individuals and those with minimal education.
- No statistically significant adverse effects on infant health outcomes (low Apgar, low birth weight) were detected.
Conclusions:
- Physicians, particularly younger ones, rapidly adapted their clinical judgment to new medical evidence, even before formal policy changes.
- The study demonstrates physician responsiveness to high-profile research reversals, influencing practice patterns.
- Despite practice shifts, infant health outcomes remained stable, suggesting the original trial's recommendations may not have been optimal for all outcomes.
Related Concept Videos
Obedience
32.9K
According to obedience research, we may harm others under the forceful pressures of an authority figure (Milgram, 1974). How about if the inappropriate orders were delivered with less force? The increasing interdependence between nurses and physicians compelled Hofling and his colleagues to explore nurses’ reactions to a potentially harmful medical request made by the perceived authority figure, the doctor (Hofling, Brotzman, Dalrymple, Graves, & Pierce, 1966). In this situation,...
32.9K
Clinical Trials: Overview
2.9K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
2.9K
Clinical Trials
6.7K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
6.7K
Factors Affecting Drug Response: Overview
2.0K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K
The Placebo Effect
6.1K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.1K
Pharmacovigilance
815
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
815

