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Natural Products Have Increased Rates of Clinical Trial Success throughout the Drug Development Process.

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Natural products (NPs) and their derivatives show increasing success in clinical trials and possess lower toxicity. Prioritizing these compounds offers a promising avenue for drug development.

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Area of Science:

  • Drug discovery and development
  • Natural product chemistry
  • Medicinal chemistry

Background:

  • Natural products (NPs) and their derivatives are significant sources of approved drugs.
  • Understanding the role of NPs in various drug development stages is crucial.

Purpose of the Study:

  • To investigate the prevalence and success rates of natural products (NPs) and their derivatives in early and late-stage drug discovery.
  • To identify factors contributing to the success of NP-based drug development.

Main Methods:

  • Analysis of patent applications over several decades to assess early-stage drug development.
  • Evaluation of clinical trial data (Phases I-III) for NP, NP-derived, and synthetic compounds.
  • In vitro and in silico toxicity assessments of NPs versus synthetic compounds.

Main Results:

  • Patent analysis showed a consistent ~23% proportion of NP and NP-derived compounds versus ~77% synthetic compounds.
  • Clinical trial data indicated an increasing trend for NP and NP-derived compounds from Phase I (35%) to Phase III (45%), with a decrease in synthetics.
  • NPs and their derivatives demonstrated lower toxicity in in vitro and in silico studies compared to synthetic counterparts.

Conclusions:

  • Natural products and their derivatives represent a valuable resource in drug discovery, with a growing presence in clinical trials.
  • Lower toxicity profiles suggest NPs may offer safer therapeutic alternatives.
  • Prioritizing natural products as starting points for drug development holds significant potential for success.