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Related Experiment Video

Updated: Jun 21, 2025

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Engineering Sonosensitizer-Derived Nanotheranostics for Augmented Sonodynamic Therapy.

Fuhong Yang1, Jingqi Lv1, Wen Ma1

  • 1Strait Institute of Flexible Electronics (SIFE, Future Technologies), Fujian Key Laboratory of Flexible Electronics, Fujian Normal University and Strait Laboratory of Flexible Electronics (SLoFE), Fuzhou, 350117, China.

Small (Weinheim an Der Bergstrasse, Germany)
|July 6, 2024
PubMed
Summary
This summary is machine-generated.

Sonodynamic therapy (SDT) shows promise for deep tumors but faces challenges. Enhancing SDT involves optimizing sonosensitizers, overcoming the tumor microenvironment (TME), and combining it with other therapies for better outcomes.

Keywords:
combinational therapyconquering hypoxiasonodynamic therapysonosensitizer optimization

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Area of Science:

  • Biomedical Engineering
  • Oncology
  • Nanotechnology

Background:

  • Sonodynamic therapy (SDT) offers noninvasive treatment for deep-seated tumors.
  • Current SDT efficacy is limited by the complex tumor microenvironment (TME) and inherent process limitations.

Purpose of the Study:

  • To review strategies for enhancing SDT therapeutic effects.
  • To focus on combining SDT with other treatment modalities for improved cancer therapy.

Main Methods:

  • Summarizing approaches including sonosensitizer optimization.
  • Detailing strategies to overcome hypoxia in the TME.
  • Reviewing combination therapies: chemodynamic, photodynamic, photothermal, chemotherapy, starvation, gas, and immunotherapy.

Main Results:

  • Identified key strategies to improve SDT efficiency.
  • Highlighted the potential of combinatorial approaches for synergistic effects.
  • Discussed challenges and provided feasible solutions for enhanced therapeutic outcomes.

Conclusions:

  • Optimizing sonosensitizers and addressing TME hypoxia are crucial for SDT.
  • Combination therapy significantly augments SDT efficacy against tumors.
  • Further research into nanotheranostics can accelerate clinical translation of SDT.