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The Spindle Assembly Checkpoint

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...

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Related Experiment Video

Updated: Jun 21, 2025

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays

Published on: June 9, 2015

Spindle Epithelial Tumor with Thymus-Like Elements (SETTLE)

Rumeal D Whaley¹, Andrew L Folpe², Lori A Erickson²

¹Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. Whaley.Rumeal@mayo.edu.

Endocrine Pathology

|July 6, 2024

Summary

No abstract available in PubMed .

Keywords:

Genetics Molecular SETTLE Spindle epithelial tumor with thymus-like elements Thyroid gland

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