Related Experiment Video
Updated: Jun 21, 2025

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
Primary central nervous system vasculitis with intracranial aneurysm
Carlo Salvarani1, Robert D Brown2, Teresa J H Christianson3
1Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA; Rheumatology Division, Azienda USL-IRCCS di Reggio Emilia e Università di Modena e Reggio Emilia, Reggio Emilia, Italy.
Unruptured intracranial aneurysms (UIAs) are uncommon in primary central nervous system vasculitis (PCNSV). This study found that UIAs in PCNSV patients did not significantly differ clinically, but were associated with reduced disability.
Area of Science:
- Neurology
- Vascular Neurology
- Neuroimmunology
Background:
- Primary central nervous system vasculitis (PCNSV) rarely involves unruptured intracranial aneurysms (UIAs).
- Understanding the characteristics and outcomes of UIAs in PCNSV is crucial for patient management.
Purpose of the Study:
- To describe the clinical findings, treatment response, and outcomes of UIAs in a large cohort of PCNSV patients.
- To compare the characteristics of PCNSV patients with and without UIAs.
Main Methods:
- Retrospective study of 216 PCNSV patients over 40 years.
- UIAs identified via cerebral angiography.
- Clinical, radiological, and pathological data analyzed and compared between UIA and non-UIA groups.
Main Results:
- 5.5% of PCNSV patients had at least one UIA.
- Headache and neurological deficits were common presenting symptoms.
- UIAs remained stable during follow-up; no new aneurysms developed.
- PCNSV patients with UIAs showed reduced disability at follow-up compared to those without.
Conclusions:
- Unruptured intracranial aneurysms are an uncommon finding in primary central nervous system vasculitis.
- The presence of UIAs in PCNSV does not appear to significantly alter clinical presentation but may be associated with better long-term functional outcomes.
More Related Videos
10:50Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
Published on: March 26, 2019
09:35Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
Related Concept Videos
Arteries of the Head and Neck
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
The Arch of Aorta
Encircling the heart, the coronary arteries form a ring-like structure before...
Vascular Spasm
Cranial and Spinal Meninges
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Veins of Head and Neck
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...