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Updated: Jun 21, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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Synthesis and evaluation of 3,4,5-trisubstituted triazoles as G protein-biased kappa opioid receptor agonists

Ashley E Trojniak1, Vuong Q Dang2, Kerri M Czekner3

  • 1Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7363, USA.

European Journal of Medicinal Chemistry
|July 6, 2024
PubMed

Keywords:
Biased agonistBioisostereKappa opioid receptorMicrosomal stabilityStructure–activity relationships

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