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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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TRIAL-based combination therapies in cancers.

Qiumin Deng1, Luxuan Chen1, Gui Zhang1

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International Immunopharmacology
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Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) shows promise for cancer treatment. Combining TRAIL with other drugs effectively overcomes cancer cell resistance, enhancing therapeutic outcomes.

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Area of Science:

  • Molecular Biology
  • Cancer Therapeutics
  • Apoptosis Signaling

Background:

  • Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in cancer cells via extrinsic pathways.
  • Cancer cells frequently develop resistance to TRAIL monotherapy, limiting its clinical application.
  • Overcoming TRAIL resistance is crucial for developing effective anti-cancer strategies.

Purpose of the Study:

  • To review combination therapy approaches for overcoming TRAIL resistance in cancer.
  • To highlight various drug classes used in conjunction with TRAIL.
  • To provide a foundation for advancing TRAIL-based cancer treatments.

Main Methods:

  • Literature review of TRAIL combination therapies.
  • Analysis of different drug classes combined with TRAIL.
  • Evaluation of synergistic effects and sensitization of resistant cancer cells.

Main Results:

  • Combination strategies effectively counteract TRAIL resistance in various cancers.
  • Synergistic effects observed when TRAIL is combined with other potent agents.
  • Sensitization of drug-resistant cancer cells is a key outcome.

Conclusions:

  • Combining TRAIL with other drugs is a viable strategy to overcome cancer resistance.
  • This approach enhances the therapeutic potential of TRAIL in cancer treatment.
  • Findings support future development of advanced TRAIL-based combination therapies.