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ESF1 positively regulates MDM2 and promotes tumorigenesis

  • 0Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Biological Products, Laoshan Laboratory, Qingdao, China.
International Journal of Biological Macromolecules +

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July 6, 2024

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July 6, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Eighteen S rRNA factor 1 (ESF1) promotes tumor progression by stabilizing MDM2 and preventing p53 activation. Increased ESF1 expression correlates with poor survival in multiple cancers, including pancreatic cancer.

Area Of Science

  • Molecular Biology
  • Cancer Research
  • Cell Biology

Background

  • Eighteen S rRNA factor 1 (ESF1) is a nucleolar protein crucial for embryogenesis.
  • Previous research indicated Esf1 acts as a negative regulator of the tumor suppressor p53.
  • The role of ESF1 in tumorigenesis remained largely unexplored.

Purpose Of The Study

  • To investigate the role of ESF1 in cancer development and progression.
  • To elucidate the molecular mechanisms by which ESF1 influences the MDM2-p53 pathway.

Main Methods

  • Analysis of ESF1 expression in human tumors and correlation with patient survival.
  • Assessment of ESF1's impact on cell proliferation, migration, and apoptosis.
  • Investigation of ESF1's interaction with MDM2 and its effect on MDM2 ubiquitination and p53 stability.

Main Results

  • Elevated ESF1 expression is linked to poorer survival in various cancers, notably pancreatic cancer.
  • ESF1 modulates cell proliferation, migration, DNA damage-induced apoptosis, and overall tumorigenesis.
  • ESF1 physically interacts with MDM2, inhibiting MDM2 ubiquitination and enhancing its stability.
  • ESF1 suppresses stress-induced p53 stabilization in cancer cells.

Conclusions

  • ESF1 is a significant regulator of the MDM2-p53 pathway.
  • ESF1 promotes tumor progression through its interaction with MDM2 and modulation of p53.
  • ESF1 represents a potential therapeutic target in cancer treatment.

Keywords:

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