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Updated: Jun 21, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Targeted Therapy Innovations for Melanoma
Dahiana Amarillo1, Keith T Flaherty2, Ryan J Sullivan3
1Oncóloga Médica, Departamento Básico de Medicina, Universidad de la República, Montevideo, Uruguay.
Abstract:
Melanoma, a malignant tumor of melanocytes, poses a significant clinical challenge due to its aggressive nature and high potential for metastasis. The advent of targeted therapy has revolutionized the treatment landscape of melanoma, particularly for tumors harboring specific genetic alterations such as BRAF V600E mutations. Despite the initial success of targeted agents, resistance inevitably arises, underscoring the need for novel therapeutic strategies. This review explores the latest advances in targeted therapy for melanoma, focusing on new molecular targets, combination therapies, and strategies to overcome resistance.
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