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Structurally diverse diterpenoids from the leaves of Croton mangelong and their anti-diabetic activity
Zhi-Yong Jiang1, Qi Niu2, Hao-Xin Wang2
1School of Ethnic Medicine, Yunnan University of Chinese Medicine, Kunming, 650500, Yunnan, PR China; Key Laboratory of Modern Research on Ethnic Medicine in Colleges of Yunnan Province, Kunming, 650500, Yunnan, PR China; Key Laboratory of Dai & Yi Medicine in Yunnan Province, Kunming, 650500, Yunnan, PR China.
Abstract:
Eighteen compounds including eleven previously undescribed diterpenes were isolated from the leaves of Croton mangelong. The structures were determined by HRESIMS, IR, NMR, X-ray diffraction and ECD spectroscopic analysis. All isolates were assayed for their anti-hyperglycemic activities in insulin resistance (IR) 3T3-L1 adipocytes, and compound 4 was tested for its anti-diabetic activity in vivo. Results suggested compound 4 could effectively reduce blood glucose level in diabetic SD rats in a dose of 30 mg/kg.
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