Related Experiment Video
Updated: Jun 21, 2025
08:34
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
20.3K
Stereotactic Body Proton Therapy Versus Conventionally Fractionated Proton Therapy for Early Prostate Cancer: A
Diego A S Toesca1, William F Hartsell2, Todd A DeWees3
1Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona.
Summary
Stereotactic body proton therapy (SBPT) is as effective as conventionally fractionated proton therapy (CFPT) for early prostate cancer. Both treatments demonstrated similar cancer control and quality of life outcomes with comparable toxicity.
Area of Science:
- Oncology
- Radiation Oncology
- Proton Therapy
Background:
- Early prostate cancer treatment involves various modalities.
- Proton therapy offers precise radiation delivery.
- Ultrahypofractionated regimens are being explored to optimize treatment schedules.
Purpose of the Study:
- To compare the efficacy and safety of stereotactic body proton therapy (SBPT) versus conventionally fractionated proton therapy (CFPT) for early prostate cancer.
- To determine if SBPT is noninferior to CFPT in terms of cancer control.
Main Methods:
- A multicenter, randomized, controlled, noninferiority phase 3 trial.
- Patients with low-risk prostate adenocarcinoma were assigned to SBPT (38 Gy/5 fractions) or CFPT (79.2 Gy/44 fractions).
- The primary endpoint was freedom from failure (FFF) at 2 years, with toxicity and quality of life assessed.
Main Results:
- The 2-year FFF rate was 100% in both groups, meeting noninferiority criteria for SBPT.
- No significant differences were observed in gastrointestinal or genitourinary toxicities between SBPT and CFPT.
- Patient-reported quality of life metrics remained similar between the two treatment arms over the follow-up period.
Conclusions:
- Stereotactic body proton therapy (SBPT) is noninferior to conventionally fractionated proton therapy (CFPT) for early prostate cancer.
- Both treatment approaches show comparable long-term efficacy and safety profiles.
- SBPT offers a comparable alternative to CFPT with similar patient-reported outcomes.
