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Related Experiment Videos

Blood-brain barrier and peptides.

A Ermisch, H J Rühle, R Landgraf

    Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
    |September 1, 1985
    PubMed
    Summary

    Blood-borne peptides are extracted by the brain, but unlikely reach neurons in significant amounts. However, these peptides can alter blood-brain barrier (BBB) permeability, potentially impacting brain function.

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    Area of Science:

    • Neuroscience
    • Endocrinology
    • Physiology

    Background:

    • The brain produces and receives peptide signals, raising questions about the influence of blood-borne peptides on brain function.
    • The blood-brain barrier (BBB) tightly regulates substance entry into the brain.

    Purpose of the Study:

    • To investigate whether endogenous, blood-borne peptides influence brain function.
    • To quantify peptide extraction by different brain regions and assess their potential to cross the BBB.

    Main Methods:

    • Intracarotid bolus injection of labeled peptide molecules in rats.
    • Measurement of peptide extraction fractions in various brain regions, including those with tight (BBB) and leaky capillaries.
    • Investigation of peptide binding to endothelial cells of the BBB.

    Main Results:

    • Low but measurable amounts of various peptides (e.g., arginine-vasopressin, beta-endorphin) were extracted by BBB-protected brain regions.
    • Extraction fractions ranged from 0.5% to 2.4% and were similar across 15 examined regions.
    • Peptides reached cellular elements in circumventricular organs with leaky capillaries, but not definitively in deeper brain neurons.
    • Blood-borne peptides were shown to influence BBB permeability, possibly via binding sites on endothelial cells.

    Conclusions:

    • While direct neuronal access is unlikely for most blood-borne peptides, they can influence brain function by altering BBB permeability.
    • Specific binding sites on the BBB endothelium may mediate peptide effects on barrier function.
    • The modulation of BBB permeability by peptides might be crucial for normal brain function.

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